Marinka Zitnik

Fusing bits and DNA

  • Increase font size
  • Default font size
  • Decrease font size
Home

Nature Communications: Mapping Biological Functions of NUDIX Enzymes

Our new study published in Nature Communications explores the NUDIX hydrolases in human cells and provides attractive opportunities for expanding the use of this enzyme family as biomarkers and potential novel drug targets. The NUDIX enzymes are involved in several cellular processes, yet their biological role has remained largely unclear.

In a collaborative study with Karolinska Institutet, Helleday Laboratory, Science for Life Laboratory (SciLifeLab)Uppsala University, Stockholm University, and the Human Protein Atlas we have generated comprehensive data on the individual structural, biochemical and biological properties of 18 human NUDIX proteins, as well as how they relate to and interact with each other.

I am especially happy to see how my machine learning and computational biology methods can help discover new biology! We used my recent methods for data fusion and gene network inference to generate predictions, which we then validated in the wet laboratory. Using these novel algorithms, we integrated all data and created a comprehensive NUDIX enzyme profile map. This map reveals novel insights into substrate selectivity and biological functions of NUDIX hydrolases and poses a platform for expanding the use of NUDIX as biomarkers and potential novel cancer drug targets.

Karolinska Institutet NewsScience for Life Laboratory (SciLifeLab) News, and by Phys.org News wrote about this project.